I’m Ke Zhu, a Postdoctoral Research Scholar jointly affiliated with North Carolina State University and Duke University, mentored by Dr. Shu Yang and Dr. Xiaofei Wang. I received my PhD from Tsinghua University, where I was advised by Dr. Hanzhong Liu.
My research focuses on developing statistical methodology and theory for causal inference, data integration, and uncertainty-aware machine learning. Driven by real-world challenges, I apply these methods to clinical trials, precision medicine, and policy evaluation.
My CV is available here.
News
Our invited session, Learning Across Boundaries: Statistical and Machine Learning Methods for Biomedical Data Fusion, has been accepted for JSM 2026 this August.
Our invited session, AI/ML-related Inference, with Applications in Biomedical Research, has been accepted for ICSA 2026 this June.
Our invited session, Conformal Inference for Uncertainty-Aware Machine Learning in Biomedical Research, has been accepted for DISS 2026 this April.
My oral presentation, “Robust Estimation and Inference in Small Hybrid Controlled Trials with Conformal Selective Borrowing,” has been accepted for ENAR 2026 this March. [Slides]
Professional Experience
Guest Associate Editor, Statistics in Biopharmaceutical Research, 2026–2027
Special Issue on “Externally Controlled Trials: Tutorials, Reviews, and Practical Guidance”Fellow, FDA-OCE-ASA Oncology Educational Fellowship, 2025–2026
Member / Sub-team Co-leader, ASA Biopharmaceutical Section Real World Evidence Scientific Working Group, 2024–present
Hybrid Trial Designs Team
Publications
(† indicates co-first author; * indicates corresponding author)
[1] Yi Liu, Ke Zhu, Larry Han, and Shu Yang* (2026). COADVISE: Covariate adjustment with variable selection in randomized controlled trials. Journal of the Royal Statistical Society: Series A, in press. [Package]
[2] Yi Liu, Alexander W. Levis, Ke Zhu, Shu Yang, Peter B. Gilbert, and Larry Han* (2026). Privacy-protected causal survival analysis under distribution shift. The 14th International Conference on Learning Representations (ICLR). [Package]
[3] Ke Zhu, Shu Yang*, and Xiaofei Wang (2025). Enhancing statistical validity and power in hybrid controlled trials: A randomization inference approach with conformal selective borrowing. Proceedings of the 42nd International Conference on Machine Learning (ICML), PMLR, 267: 80282-80309. [Slides] [Poster] [Package] [Code]
** Winner of the NISS New Researcher Presentation Award at the NISS Virtual New Researchers Conference
** Winner of the NSF Travel Award for the 10th Workshop on Biostatistics and Bioinformatics
[4] Ke Zhu†, Jianing Chu†, Ilya Lipkovich, Wenyu Ye, and Shu Yang* (2025). Doubly robust fusion of many treatments for policy learning. Proceedings of the 42nd International Conference on Machine Learning (ICML), PMLR, 267: 79772-79789. [Slides] [Poster]
[5] Haoyang Yu, Ke Zhu*, and Hanzhong Liu (2025). Sharp variance estimator and causal bootstrap in stratified randomized experiments. Statistics in Medicine, 44(13-14): e70139. [Paper] [Package] [Code]
[6] Ke Zhu, Hanzhong Liu*, and Yuehan Yang* (2025). Design-based theory for lasso adjustment in randomized block experiments and rerandomized experiments. Journal of Business & Economic Statistics, 43(3): 544-555. [Paper] [Slides] [Code]
[7] Ke Zhu, and Hanzhong Liu* (2024). Rejoinder to reader reaction “On exact randomization-based covariate-adjusted confidence intervals” by Jacob Fiksel. Biometrics, 80(2): ujae052. [Paper] [Code]
[8] Ke Zhu, and Hanzhong Liu* (2023). Pair-switching rerandomization. Biometrics, 79(3): 2127-2142. [Paper] [Code]
[9] Ke Zhu, and Hanzhong Liu* (2022). Confidence intervals for parameters in high-dimensional sparse vector autoregression. Computational Statistics & Data Analysis, 168: 107383. [Paper]
Submitted Papers
[10] Ke Zhu, Rima Izem, Peng Yang, Ying Yuan, Herbert Pang, Mark van der Laan, Lei Nie, Birol Emir, Pallavi Mishra-Kalyani, Hana Lee, and Shu Yang* (2026). Externally Controlled Trials: A Review of Design and Borrowing Through a Causal Lens.
[11] Chenxi Li, Ke Zhu, Shu Yang, and Xiaofei Wang* (2026). Selective Information Borrowing for Region-Specific Treatment Effect Inference under Covariate Mismatch in Multi-Regional Clinical Trials.
[12] Yi Liu, Alexander W. Levis, Ke Zhu, Shu Yang, Peter B. Gilbert, and Larry Han* (2025). Targeted Data Fusion for Region-Specific Survival Effects in the AMP HIV Prevention Trials.
[13] Jiajun Liu†, Ke Zhu†, Shu Yang, and Xiaofei Wang* (2025). Robust estimation and inference in hybrid controlled trials for binary outcomes: A case study on non-small cell lung cancer. [Package]
[14] Tingxuan Han†, Ke Zhu†, Hanzhong Liu*, and Ke Deng* (2025). Imputation-based randomization tests for randomized experiments with interference. [Package]
[15] Jiuyao Lu, Tianruo Zhang, and Ke Zhu* (2025) Fast rerandomization for balancing covariate in randomized experiments: A Metropolis–Hastings framework.
[16] Xin Lu, Wanjia Fu, Hongzi Li, Haoyang Yu, Honghao Zhang, Ke Zhu*, and Hanzhong Liu (2025). Design-based Theory for Causal Inference (in Chinese).
Interdisciplinary Collaborations
[17] Fei Xia, Ke Zhu, Yuanyuan Ren, and Ningyu Wang* (2024). Efficacy of the automated mechanical repositioning chairs treatment for patients with benign paroxysmal positional vertigo. The Journal of Laryngology and Otology, in press.
[18] Chenhao Hu, Ke Zhu, Kun Huang, Bo Yu, Wenchen Jiang, Kaiping Peng, and Fei Wang* (2022). Using natural intervention to promote subjective well-being of essential workers during public-health crises: A study during the COVID-19 pandemic. Journal of Environmental Psychology, 79: 101745.
[19] Huachen Zhang, Ke Zhu, Jiangdian Wang, and Xianli Lv* (2022). The use of a new classification in endovascular treatment of dural arteriovenous fistulas. Neuroscience Informatics, 2(2): 100047.
[20] Ke Zhu†, Yingkai Jiang†, Xiang Wang, Zhicheng Shi, Chao Yang, Hanzhong Liu*, and Ke Deng* (2022). A new framework of customized production product certification based on the combination of domain knowledge and data inference (in Chinese). Chinese Journal of Applied Probability and Statistics, 38(4), 581–602.